Do this before you accept the prize money. I will need advisers to set up trusts for minimizing taxes, directing charitable giving and estate planning. I have a very good Dr. who I would ask for help on finding these advisers.
Hire a lawyer, an accountant, a financial planner and maybe an insurance adviser.
First the tax expert, then the investment adviser.
Talk to the accountant or tax attorney to figure out what my tax options are and find out how much money I will end up with after taxes.
Then hire a financial planner.
Financial Planner Board of Standards
http://www.cfp-board.org/
The National Association of Personal Financial Advisors
http://www.napfa.org/
Take the cash option but still pick conservative investments such as municipal bonds and blue chip stocks, aiming for something like a 6 percent return. I don't want to take a lot of risk.
Other things you may want to do.
Don't tell anyone. Don't do anything rash. At least for a few weeks, keep your job, keep your house and keep in touch with close friends, relatives.
Don't make grand promises in the heat of the moment to family members. Instead, wait until you've had time to talk with your advisors and get a sense of your true financial situation.
You may want to take a picture while holding the ticket, photocopy it front and back, and then put it away.
When you claim your money, no press conferences, no pictures, no commercials.
Well that all I can think of for now.